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Mtphagy Dye
CAS No. 2137473-96-0
Mtphagy Dye( —— )
Catalog No. M13406 CAS No. 2137473-96-0
Mtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy; has suitable fluorescent properties for detecting mitochondrial acidification during mitophagy in the long-wavelength region that does not damage mitochondria.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMtphagy Dye
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NoteResearch use only, not for human use.
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Brief DescriptionMtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy; has suitable fluorescent properties for detecting mitochondrial acidification during mitophagy in the long-wavelength region that does not damage mitochondria.
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DescriptionMtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy; has suitable fluorescent properties for detecting mitochondrial acidification during mitophagy in the long-wavelength region that does not damage mitochondria.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetMitophagy
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RecptorMitophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number2137473-96-0
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Formula Weight939.918
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Molecular FormulaC57H49Cl2N4O3P
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(2-(3-(8-(4-(4-(chloromethyl)benzyl)piperazin-1-yl)-1,3-dioxo-1H-benzo[10,5]anthra[2,1,9-def]isoquinolin-2(3H)-yl)propanamido)ethyl)triphenylphosphonium chloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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U0126
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy.
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Mtphagy Dye
Mtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy; has suitable fluorescent properties for detecting mitochondrial acidification during mitophagy in the long-wavelength region that does not damage mitochondria.
-
P62-mediated mitopha...
P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
